paper, roll, white, All of Isaac's bombs now having a homing effect when placed on the floor, * boss rush pool, boss rush room, item room, treasure room, item room pool, bomb beggar, dead, When taking damage, the cannon will break and remain broken until recharged (Recharge time: 4 rooms). pants, under wear, pink, knickers, moms underwear, mom underwear, REPENTANCE - Touching enemies deals 12 damage to them, Item Pool: Boss Room, Challenge Room, Mom's Chest, * dungeon room, blood challenge room, arena pool, boss room pool, boss room item, red, high, shoe, moms heels, mom heels, Drops a random heart on the floor when picked up, * moms lipstick, mom lipstick, dungeon room, blood challenge room, arena pool, boss room pool, boss room item, red, grey, gray, UNLOCK: Unlock this item by beating Mom's Heart 4 times, Gives Isaac angel wings for the current room, allowing him to fly, Instantly kills the Mom's Foot, Mom's Heart and It Lives boss fights, If used during the Satan fight, The Bible will instantly kill Isaac, Counts as 1 of 3 angel items needed towards the Seraphim transformation, REPENTANCE - Reduced to 4 room recharge time, * library pool, library room, book room pool, angel room pool, god room pool, angel room item, If you have PhD it will only increase one stat, Can be used multiple times, but every time you use it, it has a chance to disappear, The Gold Pill can spawn as a Horse Pill, which then causes it to give random Horse pill effects, UNLOCK: Unlock this by defeating Mega Satan as Tainted Cain, Horse Pills rarely spawn as larger versions of normal pills with more powerful effects, Items that synergize with pills also have the same effect with Horse pills, In general, the effect of a Horse Pill is double the effect of a normal pill i.e. This means you need a way to teleport out of the Mom's Foot boss fight. ?, Satan and The Lamb as Tainted Eve, A small clot friend will hug Isaac, following his exact movements (similar to how Jacob & Esau work) and shooting tears when he does, The clot can be moved around by collision with an object/wall, allowing you to re-position it, The clot's damage is roughly 1/3 of your tear damage, If it takes a few hits it will die, and respawn in the next room, UNLOCK: Unlock this trinket by defeating Mother as Tainted Eve, Spawns a random chest after completing a regular Challenge Room, Spawns a pedestal item after completing a boss Challenge Room, UNLOCK: Unlock this trinket by defeating Isaac, ?? The charge direction now allows for a minor amount of control, * headless horseman, headless horsemen, red, grey, gray, A bag of bombs that will drop a bomb pickup every 2 rooms, UNLOCK: Unlock this item by beating Satan with Cain, * boss rush pool, boss rush room, secret room pool, item room, treasure room, item room pool, card will teleport you to the I AM ERROR room, UNLOCK: Unlock this item by beating the Isaac boss with Eden, * secret room pool, shop room pool, shop item pool, item room, treasure room, item room pool, Honestly, Repentance probably adds the fewest "bad" unlocks out of any version of isaac ever. A familiar fly that moves in a straight line and attaches itself to the first obstacle or wall it comes into contact with in each room. Tears can still hit Isaac if gravity applies for too long, Allows Isaac to squeeze between some objects, This item has a chance to spawn an additional curse room on each future floor, Causes a penny to spawn in all future Curse Rooms, Tears fired from your left eye gain roughly +28% fire rate increase, Causes your tears to be fired at staggered rates, Allows Angel Rooms to appears even if a Devil deal has been taken before, All shops now contain a trapdoor with a ladder, which leads down to a special shop. This deals 1 damage per tick, High tear damage will cause this item to become very powerful for rooms with a lot of enemies, since they can die instantly and render the room harmless, Enemies which spawn after the first few seconds of each room are not affected by this item, e.g. This gives you his ability to fly, and the Holy Mantle effect. 11 Death Certificate. If you touch an enemy in that time, Isaac will pick it up and slam it on the ground, killing it and sending a shockwave around the impact, In the brief period while holding the enemy you can move a target to decide where it lands, Actually does work on bosses! If you get hit in either of the other 2 states you will not be teleported, The Black Candle item will remove the Cursed Eye's teleportation effect, REPENTANCE - Burst now has 5 shots instead of 4, * secret room pool, item room, treasure room, item room pool, white, circle, pearl, When Isaac's tears hit anything, they leave a green toxic creep on the floor that damages enemies for 1 damage per tick, * item room, treasure room, item room pool, mystery liquid, grey, gray, green, A familar that is attached to Isaac, which will seek out and damage any enemies close by for 3 contact damage, * astrology, astronomy, item room, treasure room, item room pool, blue, glow, A familiar eye that follows Isaac and copies all his tear modifiers/effects, but shoots in random directions, Tears from this familiar deal 75% of Isaac's tear damage, UNLOCK: Unlock this item by beating Boss Rush with Cain, * item room, treasure room, item room pool, eyeball, white, circle, cataract, cains other eye, A familiar fly that can be moved around via use of the arrow keys dealing 2.5 contact damage per tick, similar to the Ludovico Technique's mechanic, UNLOCK: Unlock this item by beating Boss Rush with Blue Baby, * item room, treasure room, item room pool, blue fly, big fly, blue baby's only friend, fat, dead, ?? (Does not roll your devil deal items), 5 Dot - Reroll and restart the current floor (Forget Me Now effect), 6 Dot - Reroll all of your items and all the pickups on the entire floor (Combined 1 + 3 + 4 rooms), The same order as the in-game collection page. in an Angel room, this will spawn 2 Angel room items), Starts with 0 charge and requires 12 charges to use, UNLOCK: Unlock this item by defeating Delirium in The Void floor with Eden, Every 6-7 rooms Acid Baby will drop a random pill, Every time you use a pill, Acid Baby will deal 10 damage to all enemies and poison them for 6-7 ticks, REPENTANCE - Poison effect is stronger, but Acid Baby's pill drop rate has been reduced to every 6-7 rooms (previously every 2-3 rooms), A familiar fairy that will float around the room and highlight the location of any secret room doors, tinted rocks or trapdoors under rocks, Upon entering a new room, if there is an undiscovered secret room or tinted rock, it will move directly to the point of interest, otherwise it will just randomly fly around the room, For every empty red heart container, Isaac gains Damage Up and his body increases in size, Only works on full hearts - damage does not change if Isaac is missing 1/2 of a heart in one container, Healing empty red heart containers will remove the damage increases, Has no effect for The Lost and ?? UNLOCK: Unlock this card by beating Challenge #9 (Demo Man), Temporarily makes Isaac huge, giving him +7 Damage Up and +30 Range Up for the rest of the current room, Added as part of the Afterbirth+ Booster Pack #1 and based on the Steam Workshop mod created by Coper140, UNLOCK: Unlock this item by getting 5 items or consumables that increase your size, e.g. Holy Light: Holy tears are a great source of extra damage. Godhead: A item that gives you amazing tears. Based on the Steam Workshop mod created by Amethyst, UNLOCK: Unlock this item by using 5 Gulp! UNLOCK: Unlock this card by defeating Ultra Greedier mode as Tainted Bethany, Spawns a random pedestal item from the current room's item pool, In exchange, turns one heart container or 2 soul hearts into a broken heart. Every 6 coins Bumbo will evolve to a new form except for level 4 which takes 12 coins, Level 2: Bumbo gains a body and crawls around the room, sometimes dropping random pickups, Level 3: It now fires tears in the same direction Isaac does, Level 4: Bumbo no longer fires tears but instead will chase enemies slowly and deal contact damage. grey, gray, feet bobby bomb, When used, deals damage to Isaac in exchange for +1.2 damage up which lasts for the current room, The first use per room takes 1 full heart, then 0.5 hearts per use after that. The Forgotten - Your Soul is now unchained and free to move. The Planetarium is a type of room that is featured in The. This item will modify drops from room clearing and champion enemies based on your current player state. red, drip, Isaac's health is set to 1 and he also gains 9 extra lives, Each time Isaac dies, he will respawn with 1 Health, Has a chance to drop from the Super Pride mini boss, The floating Dead Cat head that follows you will disappear when you are on your last life (Very useful for The Lost), Item Pool: Devil Room, Curse Room, Red Chest, Super Pride Miniboss, * curse room pool, red chest pool, red chest item pool, devil pool, devil room pool, devil deal, Gives Isaac demon wings and the ability to fly, * devil pool, devil room pool, devil deal, the lost item pool, cross, upside down, red, black. No longer has an "on hit" effect, UNLOCK: Unlock this item by donating 999 pennies to the Shop, * shop room pool, shop item pool, stopwatch, blue, pocket, clock, Tears now revolve around Isaac's Body at a fixed distance until they hit the ground, Aiming in the opposite direction is often better due to how the tears circle around Isaac, Causes a lot of great synergies with items such as Lump of Coal, Brimstone, Rubber Cement, Technology and most of the worm trinkets, REPENTANCE - Tiny Planet's orbit now more tightly follows Isaac. poison effect for Pestilence, Added as part of the Afterbirth+ Booster Pack #3. One exception to this is if you are playing as Lazarus or have Lazarus' Rags - you will respawn in the same room and get the kill, Plan C is 5 times rarer than other items in the same item pool, making it less likely to appear, UNLOCK: Unlock this item by defeating Greedier Mode with Lazarus, Item Pool: Shop, Devil Room, Curse Room, Red Chest, Demon Beggar, When used, the D1 duplicates 1 random pickup in the current room. Stat Down pills do nothing, and items like Experimental Treatment increase stats but don't reduce any, This effect works on items that apply negative stat modifiers, such as Soy Milk, This effect works for anything that gives temporary buffs, like Devil/Strength cards, or kill bonuses like Bloody Lust, If you somehow lose Rock Bottom, your stats will go back to normal, UNLOCK: Unlock this item by defeating the Boss Rush as Jacob & Esau, Bombs now explode with a random effect (e.g. See the dedicated Devil room page for more details, First half of the key required to enter the door to the Mega Satan boss, Drops from one of the angels which appear by bombing the statue in an angel room, * angel room, angels, broken, yellow, gold, circle, Second half of the key required to enter the door to the Mega Satan boss, Randomly increases 4 of your stats, and decreases 2 of them, Possible stat changes are fixed values: 1 health, 1 damage, 0.2 speed, 0.5 range, 0.5 tears, 0.2 shot speed, 1 luck, UNLOCK: Unlock this item by beating Mom's Heart 7 times, * demon beggar pool, demon judgement pool, devil beggar pool, boss room pool, boss room item, item room, treasure room, item room pool, yellow syringe, needle, injection, Doubles pickups and chests from clearing a room, Also gives a 30% chance for room clear rewards to not spawn, Doesn't affect coins spawned in Greed Mode, * curse room pool, demon beggar pool, demon judgement pool, devil beggar pool, devil pool, This is located on Corpse II, which requires a certain sequence of events. best places to live in south carolina mountains. e.g. This room will always drop a reward at the end, then allow you to exit back to the real floor, UNLOCK: Unlock this trinket by defeating The Beast as Tainted Cain, While held this trinket causes spikes to retract into the floor, Works for curse rooms - you no longer take damage entering or leaving, Allows you to open spiked chests without taking damage, Allows Planetariums to spawn in the Womb/Utero floors, Planetarium have a base 1% chance to appear, which increases by +20% whenever you skip an Item Room (Must not enter to count as skipped), After entering a Planetarium the chance goes back to 1%. From the Sacred Heart to the Magic Mushroom and the mighty Brimstone, here are some of the best and strongest items available in The Binding Of Isaac. A familiar that follows Isaac and charges forwards very slowly, dealing 2.7 damage per tick to any enemies it comes into contact with, Almost identical to the Little Chubby familiar, but this one moves much more slowly and deals less damage, REPENTANCE - The damage tick rate on Big Chubby has been increased, Upon use, this item deals 9,999,999 damage to all enemies in the room and then kills you 3 seconds later, This is a single use active item, meaning it is destroyed after using it, Does not kill both phases of multi-phase bosses like Hush or Ultra Greed, If used to kill a boss, the kill still counts as a victory for post-it note completion marks, but the run will still get a game over, Delirium's death animation takes longer than 3 seconds, meaning you will die before it can count as a completion mark. The effect triggers again 30 seconds after use and again 60 seconds after use, Something's wrong - Spawns a pool of black creep beneath Isaac, Vurp! Now grants a half black heart upon use instead of a full soul heart. The laser hits up to 13 times if an enemy stays inside it for the duration, Has a chance to drop from the Envy and Super Envy miniboss fights, Item Pool: Item Room, Envy Miniboss, Super Envy Miniboss, * item room, treasure room, item room pool, red, lips, white, eyes, UNLOCK: Unlock this item by beating the Basement 40 times and defeating the Steven boss, *, black, white, face, eyes, mouth, golden chest pool, +10% chance of a devil/angel room opening while held, A second Pentagram will give an extra +5% chance, Counts as 1 of 3 evil items needed towards the Leviathan transformation, Item Pool: Boss Room, Curse Room, Devil Room, Demon Beggar, Crane Game, * curse room pool, devil pool, devil room pool, devil deal, boss room pool, boss room item, rocks, poop) in the room and deal 200 damage to all enemies in the current room, as well as every other room for the remainder of the floor, Also opens the boss rush door after Mom's Foot, blue womb door after Mom's Heart, secret rooms and super secret rooms, Like all single-use items, this item cannot be absorbed and used multiple times by the Void item, Entering a room with an angel statue will destroy it and automatically spawn one of the Angel mini bosses, REPENTANCE - This now blows up machines, beggars and fireplaces too, Upon use, this item will fart, pushing enemies away and causing a wave of rocks to spawn that spread outwards from Isaac in a circle, dealing 10 damage per hit to any enemies caught in it, Visually this item is very similar to Butter Bean, The rock waves can destroy destructible objects, e.g. starting, blue, white, glow, cross, You can now break obstacles by walking over them, Holes in the ground can be filled by crushing adjacent rocks, similar to how this can be done with bombs, * item room, treasure room, item room pool, cheetos, cheese, grey, gray, orange, jar, Enemies and pickups (keys, bombs etc.) The only way to remove it is via having a second trinket slot (Mom's Purse, Belly Button) or absorbing it (Marbles, Smelter, Gulp! slow, shrink, fear), Spider Mod will also randomly drop battery consumables or blue spiders when a room is completed, For the sake of simplicity for players, all damage values displayed are multiplied by 10 and rounded to the nearest number, This item is a reference to Spider853, creator of Spidermod for the original game and one of the lead developers that worked on Rebirth and its DLCs, *, robot, red, grey, gray, silver, metal, antenna, A familiar that follows Isaac and blocks tears, If a tear hits Farting Baby, there is a 10% chance for it to fart, with 3 possible effects: Charm, Poison or Knock back, Charm deals 5 damage. Find it . Unlocked from the 'U broke it!' on enemy death, on room clear, on damage taken etc. . Based on the Steam Workshop mod created by Strawrat and Aczom, UNLOCK: Unlock this item by dying to your own Ipecac explosion, Upon taking damage, you have a random chance to consume one of your currently held trinkets, gaining its effect permanently, Added as part of the Afterbirth+ Booster Pack #5. pill) or picking up the Match Stick trinket, which will burn it off you, *, insect, bug, spider, beetle, grey, gray, brown, While held, this trinket gives Isaac a familiar that shoots piercing tears that deal 3.5 damage, UNLOCK: Unlock this item by beating the Boss Rush with Isaac, At the start of a new floor, you get an eternal heart, UNLOCK: Unlock this item by beating the Dark Room with Maggy, * , the lost item pool, cross, yellow, golden, glow, maggys faith, Items which cost 2 heart containers in a deal with the devil are reduced to only cost 1 heart, UNLOCK: Unlock this item by beating Satan with Judas, * , the lost item pool, tong, red, bloody, lips, judas tongue, Creates a familiar which moves around the room in a similar fashion to The Peeper, shooting tears in the same direction as Isaac, UNLOCK: Unlock this item by beating the Dark Room with Blue Baby, *, dead, baby, blue, ?? ItemID: 588 "Radiant victory" Quality: 2. . Both charge at the same time and using Anima Sola chains both in the same spot, Significantly increases damage by +21.6, however the damage boost wears off slowly over time at a rate of roughly -0.04 per second, Every enemy you kill adds +0.02 Damage to the timed effect of Red Stew, UNLOCK: Unlock this item by defeating Satan as Jacob & Esau, When used, removes all your passive items and teleports you to Isaac's Bedroom, For every passive item removed, you are given a choice of 3 random pedestal items from any item pool. You have the Holy Mantle effect to prevent one hit per room, but taking another hit will kill you. You get a couple of seconds of invincibility to move away after, The main benefit of this Soul Stone is that it automatically activates if you die, meaning it is effectively an extra passive life while held, UNLOCK: Unlock this item by defeating Hush and Boss Rush as Tainted Lazarus, Activates the D6 and D20 effects, rerolling all items and pickups in the room. Flies spawned from a Mulligan dying, When used, the Mega Bean will freeze all enemies in the current room for a couple of seconds, deal 5 damage and poison any enemies in close proximity and send a wave of spikes across the room in the direction you are facing, The enemies in close range will take 5 damage then have a poison over time effect which deals your tear damage 4 or 6 times, The spike wave will deal 10 damage to any enemies in contact with it. , and the Holy Mantle effect a way to teleport out of the Afterbirth+ Pack. Light: Holy tears are a great source of extra damage you have the Holy Mantle effect full Soul.! 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